Concepedia

Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions

Maria Szrejder, Patrycja Rachubik, Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Ewelina Kreft, S Angielski, Agnieszka Piwkowska

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2019 · 56 citations · 42 references

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42

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

, , +17

The Rising Global Burden of Diabetes and its Complications: Estimates and Projections to the Year 2010

Angelyne Amos, Daniel J. McCarty, Paul Zimmet · Diabetic Medicine · 1997 · 1.7K citations

, , +16

A Mutation in the <i>TRPC6</i> Cation Channel Causes Familial Focal Segmental Glomerulosclerosis

Michelle P. Winn, Peter J. Conlon, Kelvin L. Lynn et al. · Science · 2005 · 1.1K citations

, , +17

Podocyte loss and progressive glomerular injury in type II diabetes.

Maria Enrica Pagtalunan, Paul L. Miller, S Jumping-Eagle et al. · Journal of Clinical Investigation · 1997 · 1.1K citations · Full text

, , +17

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function

Jochen Reiser, Krishna R. Polu, Clemens Möller et al. · Nature Genetics · 2005 · 858 citations · Full text

, , +12