Diterpenoids from <i>Euphorbia neriifolia</i> and Their Related Anti‐HIV and Cytotoxic Activity

Abstract

Fifteen diterpenoids (1-15), including three undescribed ones with ent-atisane skeleton, eupnerias G-I (1-3), were obtained from Euphorbia neriifolia. Compounds 1-3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti-HIV-1 effect, and their EC₅₀ were 6.6±3.2 and 6.4±2.5 μg mL^-1 , respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC₅₀ at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC₅₀ =0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines.