<i>cfr</i> (B), <i>cfr</i> (C), and a New <i>cfr</i> -Like Gene, <i>cfr</i> (E), in Clostridium difficile Strains Recovered across Latin America

Abstract

Cfr is a radical S -adenosyl- l -methionine (SAM) enzyme that confers cross-resistance to antibiotics targeting the 23S rRNA through hypermethylation of nucleotide A2503. Three cfr -like genes implicated in antibiotic resistance have been described, two of which, cfr (B) and cfr (C), have been sporadically detected in Clostridium difficile . However, the methylase activity of Cfr(C) has not been confirmed.