Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch

Abstract

Abstract Diterpenoid alkaloids have neroprotective activity. Herein, three napelline-type diterpenoid alkaloids 1 – 3 , two aconitine-type diterpenoid alkaloids 4 – 5 , and one isoquinline-type alkaloid 6 , as well as one lignan glycoside 7 , have been isolated from the roots of Aconitum pendulum Busch. Compounds 1 and 7 were new compounds, and their chemical structures were determined on the basis of nuclear magnetic resonance (NMR) spectra and mass spectrometry analysis. A ThT assay revealed that compound 2 showed significant disaggregation potency on the A β 1−42 aggregates. Graphical Abstract