A role for SUMOylation in the Formation and Cellular Localization of TDP-43 Aggregates in Amyotrophic Lateral Sclerosis

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Manuela Neumann, Deepak M. Sampathu, Linda K. Kwong et al. · Science · 2006 · 6.6K citations

Life Sciences, Neurology, Neuroscience +14

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Tetsuaki Arai, Masato Hasegawa, Haruhiko Akiyama et al. · Biochemical and Biophysical Research Communications · 2006 · 2.8K citations

Life Sciences, Neurology, Neuroscience +11

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

Iga Wegorzewska, Shaughn Bell, Nigel J. Cairns et al. · Proceedings of the National Academy of Sciences · 2009 · 707 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

Ya-Fei Xu, Tania F. Gendron, Yong‐Jie Zhang et al. · Journal of Neuroscience · 2010 · 575 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

Andreas C. Woerner, Frédéric Frottin, Daniel Hornburg et al. · Science · 2015 · 407 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17