Concepedia

Dual-specificity tyrosine phosphorylation-regulated kinase 1A ameliorates insulin resistance in neurons by up-regulating IRS-1 expression

Shijiao Tian, Wenming Jia, Mei Lü, Juan Zhao, Xiulian Sun

Journal of Biological Chemistry · 2019 · 19 citations · 41 references

DOIFull text

Open access

Concepts

Abstract

mice brain. Furthermore, DYRK1A overexpression ameliorated chronic high insulin-induced insulin resistance in SH-SY5Y cells as well as in primary rat neurons. These findings suggest that DYRK1A protects against insulin resistance in the brain by elevating IRS-1 expression.

References

41

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, Hoau-Yan Wang, Hala Kazi et al. · Journal of Clinical Investigation · 2012 · 1.8K citations · Full text

, , +17

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Eric van Steen, Benjamin M. Terry, Enrique J. Rivera et al. · Journal of Alzheimer s Disease · 2005 · 1.7K citations

, , +17

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

Suzanne Craft · Archives of Neurology · 2011 · 1.2K citations

, , +17

Intranasal insulin improves cognition and modulates β-amyloid in early AD

Mark A. Reger, G. Stennis Watson, P. S. Green et al. · Neurology · 2007 · 830 citations

, , +17

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Aileen M. Moloney, Rebecca J. Griffin, Suzanne Timmons et al. · Neurobiology of Aging · 2008 · 767 citations

, , +17