Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

Philip A. Kern, Subramanian Ranganathan, Chunling Li et al. · American Journal of Physiology-Endocrinology and Metabolism · 2001 · 1.9K citations

Medicine, Endocrinology, Physiology +17

Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening

K. K. Srinivasan, Bhoomi Viswanad, Lydia Asrat et al. · Pharmacological Research · 2005 · 1.9K citations

Medicine, Endocrinology, Pharmacology +10

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, Hoau-Yan Wang, Hala Kazi et al. · Journal of Clinical Investigation · 2012 · 1.8K citations · Full text

Medicine, Neurology, Neuroscience +17

Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes

Joseph J. Senn, Peter Klover, Irena Nowak et al. · Diabetes · 2002 · 877 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

Theresa R. Bomfim, Letícia Forny‐Germano, Luciana B. Sathler et al. · Journal of Clinical Investigation · 2012 · 824 citations · Full text

Life Sciences, Neurology, Neuroscience +17