Concepedia

A Novel Small-molecule WNT Inhibitor, IC-2, Has the Potential to Suppress Liver Cancer Stem Cells

Kenzo Seto, Tomohiko Sakabe, Noriko Itaba, Junya Azumi, Hiroyuki Oka, Minoru Morimoto, Yoshihisa Umekita, Goshi Shiota

Anticancer Research · 2017 · 27 citations · 13 references

DOIFull text

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Abstract

The novel derivative of small-molecule WNT inhibitor, IC-2, has the potential to suppress liver CSCs and can serve as a promising therapeutic agent to improve the prognosis of patients with HCC.

References

13

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Louis Vermeulen, Felipe de Sousa e Melo, Maartje van der Heijden et al. · Nature Cell Biology · 2010 · 1.8K citations

, , +10

Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

Zhen Yang, David Ho, Michael Ng et al. · Cancer Cell · 2008 · 1.2K citations · Full text

, , +8

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

Taro Yamashita, Junfang Ji, Anuradha Budhu et al. · Gastroenterology · 2008 · 1.1K citations · Full text

, , +11

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

Yoshinori Imamura, Toru Mukohara, Yohei Shimono et al. · Oncology Reports · 2015 · 834 citations · Full text

CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway

Stephanie Ma, Terence K. Lee, BJ Zheng et al. · Oncogene · 2007 · 769 citations

, , +9