Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors

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Life Sciences, Biochemistry, Molecular Biology +11

The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity

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Pharmacy, Oncology, Pharmacology +16

Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities

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Pharmacy, Medicinal Chemistry, Pharmacology +7

In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors.

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Medicine, Medicinal Chemistry, Pharmacology +8