Concepedia

Publication | Closed Access

Tumor-Associated Fibroblasts Promote HER2-Targeted Therapy Resistance through FGFR2 Activation

DOI

104

Citations

32

References

2019

Year

Patricia Fernández‐Nogueira, Mario Mancino, Gemma Fuster, Anna López‐Plana, Patricia Jáuregui, Vanesa Almendro, Estel Enreig, Sílvia Menéndez, Federico Rojo, Aleix Noguera‐Castells,
Clinical Cancer Research

Abstract

We have identified the TAF/FGF5/FGFR2/c-Src/HER2 axis as an escape pathway responsible for HER2-targeted therapy resistance in breast cancer, which can be reversed by FGFR inhibitors.

References

YearCitations

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