Concepedia

Publication | Open Access

Overriding Adaptive Resistance to Sorafenib Through Combination Therapy With Src Homology 2 Domain–Containing Phosphatase 2 Blockade in Hepatocellular Carcinoma

DOIFull Paper Access

81

Citations

30

References

2019

Year

Carmen Oi Ning Leung, Man Tong, Katherine Po Sin Chung, Lena Zhou, Noélia Che, Kwan Ho Tang, Jin Ding, Eunice Y. Lau, Irene Oi‐Lin Ng, Stephanie Ma,
Hepatology

Abstract

SHP2 blockade by SHP099 in combination with sorafenib attenuated the adaptive resistance to sorafenib by impeding RTK-induced reactivation of the MEK/ERK and AKT signaling pathways. SHP099 in combination with sorafenib may be a safe therapeutic strategy against HCC.

References

YearCitations

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