Sustained discontinuation of infliximab with a raising-dose strategy after obtaining remission in patients with rheumatoid arthritis: the RRRR study, a randomised controlled trial

Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial

Ravinder N. Maini, E. William St. Clair, Ferdinand C. Breedveld et al. · The Lancet · 1999 · 2.4K citations

Medicine, Pharmacology, Pharmacotherapy +17

Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial

Y P M Goekoop-Ruiterman, Jeska K de Vries‐Bouwstra, Cornelia F Allaart et al. · Arthritis & Rheumatism · 2005 · 1.5K citations · Full text

Medicine, Clinical Sciences, Pharmacotherapy +14

Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial

E. William St. Clair, Désirée van der Heijde, Josef S Smolen et al. · Arthritis & Rheumatism · 2004 · 1.2K citations

Medicine, Pharmacology, Pharmacotherapy +12

Very early treatment with infliximab in addition to methotrexate in early, poor‐prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve‐month randomized, double‐blind, placebo‐controlled trial

Mark Quinn, Philip G. Conaghan, Philip O’Connor et al. · Arthritis & Rheumatism · 2005 · 533 citations

Medicine, Clinical Sciences, Pharmacotherapy +17

Recommendations for the Primary Analysis of Continuous Endpoints in Longitudinal Clinical Trials

Craig Mallinckrodt, P. W. Lane, Dan Schnell et al. · Drug Information Journal · 2008 · 358 citations

Public Health, Biostatistics, Clinical Epidemiology +15