Food & Function · 2019 · 19 citations · 34 references
Life SciencesBiochemistryCell BiologyCellular MetabolismMetabolic RegulationMetabolismCarbohydrate MetabolismDiabetes MellitusDiabetes Mellitus BiochemistryGlycemic ControlHepatic PathophysiologyInsulin ResistanceConcentrationGlycosaminoglycan MetabolismHepatic Glucose ProductionHepatic Insulin ResistanceHypoglycemic ToxicityInsulin Resistance In HepatocytesPhosphoenolpyruvate Carboxykinase RegulationWestern Blot Analysis
) for 3 h decreased HGP by 25% in insulin resistant hepatocytes. Quantitative PCR and western blot analysis revealed that AHG also ameliorated phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). The data revealed the mechanism of AHG in alleviating HGP via activating the Akt/FoxO1 signaling pathway and suppressing the PKA/CREB signaling pathway in insulin resistant hepatocytes. This finding suggests that AHG could be a potential marine natural product for the treatment of dysregulating glucose homeostasis.
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
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