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Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase

Asymmetric CatalysisEngineeringHeterocyclicBiochemistryNatural SciencesDiversity-oriented SynthesisOrganic ChemistryBulky 1,3-CyclodiketonesHeterocycle ChemistryCarbonyl ReductaseBiomolecular EngineeringEfficient Reductive Desymmetrization