Concepedia

Silencing transcription factor FOXM1 represses proliferation, migration, and invasion while inducing apoptosis of liver cancer stem cells by regulating the expression of ALDH2

Lijian Chen, Mei-Yun Wu, Chunyi Ji, Miaoxian Yuan, Chaoyang Liu, Qiang Yin

IUBMB Life · 2019 · 37 citations · 35 references

DOI

Abstract

Our study provides evidence that silencing FOXM1 inhibits stemness of LCSCs by decreasing the expression of ALDH2, and represses the proliferation, migration, invasion, and tumorigenesis while inducing the apoptosis of LCSCs.

References

35

Global cancer statistics

Ahmedin Jemal, Freddie Bray · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

Zhen Yang, David Ho, Michael Ng et al. · Cancer Cell · 2008 · 1.2K citations · Full text

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EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

Taro Yamashita, Junfang Ji, Anuradha Budhu et al. · Gastroenterology · 2008 · 1.1K citations · Full text

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FoxM1 is required for execution of the mitotic programme and chromosome stability

Jamila Laoukili, Matthijs R. H. Kooistra, Alexandra Le Bras et al. · Nature Cell Biology · 2005 · 812 citations

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Side population purified from hepatocellular carcinoma cells harbors cancer stem cell–like properties

Tetsuhiro Chiba, Kaoru Kita, Yun‐Wen Zheng et al. · Hepatology · 2006 · 647 citations