Concepedia

Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion

Nicola M. Blythe, Katsuhiko Muraki, Melanie J. Ludlow, Vasili Stylianidis, Hamish T. J. Gilbert, Elizabeth L. Evans, Kevin Cuthbertson, Richard Foster, Joe Swift, Jing Li,

Journal of Biological Chemistry · 2019 · 174 citations · 31 references

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Concepts

Abstract

entry. In summary, cardiac fibroblasts express mechanically activated Piezo1 channels coupled to secretion of the paracrine signaling molecule IL-6. Piezo1 may therefore be important in regulating cardiac remodeling.

References

31

Enzymatic assembly of DNA molecules up to several hundred kilobases

Daniel G. Gibson, Lei Young, Ray-Yuan Chuang et al. · Nature Methods · 2009 · 10.9K citations

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Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

Bertrand Coste, Jayanti Mathur, Manuela Schmidt et al. · Science · 2010 · 3.2K citations · Full text

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Piezo1 integration of vascular architecture with physiological force

Jing Li, Bing Hou, Sarka Tumova et al. · Nature · 2014 · 1.2K citations

, , +15

Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease

Fan Dong, Abhijit Takawale, Ji‐Won Lee et al. · Fibrogenesis & Tissue Repair · 2012 · 809 citations · Full text

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Chemical activation of the mechanotransduction channel Piezo1

Ruhma Syeda, Jie Xu, Adrienne E. Dubin et al. · eLife · 2015 · 743 citations · Full text

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