Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

Cathy Tournier, Patricia Hess, Derek Yang, +7

Science

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

Sanjeev S. Ranade, Zhaozhu Qiu, Seung-Hyun Woo, +10

Proceedings of the National Academy of Sciences

Chemical activation of the mechanotransduction channel Piezo1

Ruhma Syeda, Jie Xu, Adrienne E. Dubin, +12

eLife

JNK is required for effector T-cell function but not for T-cell activation

Chen Dong, Derek Yang, Cathy Tournier, +4

Nature

Signal TransductionSignaling PathwayCell RegulationCell SignalingImmunology +7

GPR68 Senses Flow and Is Essential for Vascular Physiology

Jie Xu, Jayanti Mathur, Emilie Vessières, +22

Cell

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH ₂ -terminal kinase activation, and defects in AP-1 transcriptional activity

Di Yang, Cathy Tournier, Mark Wysk, +4

Proceedings of the National Academy of Sciences

Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in <i>Drosophila</i>

Qi Wu, Yan Zhang, Jie Xu, +1

Proceedings of the National Academy of Sciences

Hunger ResponseDilp NeuronsDrosophila Insulin-like PeptidesGastrointestinal Peptide HormoneHypothalamic Peptide +16

Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension

Sharon Barone, Stacey Fussell, Anurag Kumar Singh, +8

Journal of Biological Chemistry

Metabolic SyndromeNutritionGastrointestinal Peptide HormoneNutrient PhysiologyBiochemistry +13

Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure

Manoocher Soleimani, Sharon Barone, Jie Xu, +4

Proceedings of the National Academy of Sciences

Na-cl CotransporterNcc Ko MiceRenal FunctionAcute Kidney InjuryChronic Kidney Disease +14

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

Jingjing Duan, Jian Li, Gui-Lan Chen, +19

Science Advances