The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain

Raimond B. G. Ravelli, Benoı̂t Gigant, Patrick A. Curmi et al. · Nature · 2004 · 1.6K citations

Life Sciences, Biochemistry, Molecular Biology +14

Structural basis for the regulation of tubulin by vinblastine

Benoı̂t Gigant, Chunguang Wang, Raimond B. G. Ravelli et al. · Nature · 2005 · 730 citations

Life Sciences, Biochemistry, Molecular Biology +11

Withaferin A is a potent inhibitor of angiogenesis

Royce Mohan, Hans J. Hammers, Paola Bargagna‐Mohan et al. · Angiogenesis · 2004 · 381 citations

Medicine, Oncology, Pharmacology +11

Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor <i>α</i> (RAR <i>α</i> ) and oncogenic RAR <i>α</i> fusion proteins

Jun Zhu, Maurizio Gianni’, Eliezer Kopf et al. · Proceedings of the National Academy of Sciences · 1999 · 367 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

The Tumor Inhibitor and Antiangiogenic Agent Withaferin A Targets the Intermediate Filament Protein Vimentin

Paola Bargagna‐Mohan, Adel Hamza, Yang-eon Kim et al. · Chemistry & Biology · 2007 · 346 citations

Life Sciences, Molecular Biology, Oncology +14