Studies on Ganoderma lucidum. IV. Effects on the Disseminated Intravascular Coagulation

Abstract

Effects of aqueous extract of Ganoderma lucidum, collected in Kyoto (K) and Odawara (O), on the experimentally disseminated intravascular coagulation (DIC) in rats were investigated. K prevented the decreases of blood platelet and fibrinogen, the prolongation of prothrombin time and the increase of fibrin degradation products (FDP) at a dose of 500 mg/kg in normal rats on DIC induced by endotoxin. O prevented the decrease of blood platelet at a dose of 500 mg/kg. K and O prevented the formation of hepatic vein thrombosis induced by endotoxin in hyperlipemia rats. In order to reveal the mode of in vivo action of K and O, the activities of K and O for blood platelet aggregation, thrombin action and fibrinolytic action were examined in vitro. K and O showed inhibitory effects on blood platelet aggregation induced by collagen, and on thrombin action at concentrations of 500-1000 μg/ml.