Inhibition of JAK1 mitigates postoperative ileus in mice

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

Scott J. Rodig, Marco Antonio Meraz‐Ríos, J. Michael White et al. · Cell · 1998 · 853 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

Mathias Müller, James Briscoe, Carl Laxton et al. · Nature · 1993 · 771 citations

Life Sciences, Immunology, Molecular Biology +12

Surgical Manipulation of the Gut Elicits an Intestinal Muscularis Inflammatory Response Resulting in Postsurgical Ileus

Jörg C. Kalff, Wolfgang H. Schraut, Richard L. Simmons et al. · Annals of Surgery · 1998 · 537 citations

Medicine, Immunology, Surgery +17

Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050

Jordan S. Fridman, Peggy Scherle, Robert J. Collins et al. · The Journal of Immunology · 2010 · 463 citations · Full text

Medicine, Immunology, Pharmacology +17

Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-controlled trial

Séverine Vermeire, Stefan Schreiber, Robert Petryka et al. · The Lancet · 2016 · 439 citations

Pharmacy, Clinical Sciences, Pharmacotherapy +13