Concepedia

Injectable hydrogels for the sustained delivery of a HER2-targeted antibody for preventing local relapse of HER2+ breast cancer after breast-conserving surgery

Xiaobin Chen, Maoli Wang, Xiaowei Yang, Yaoben Wang, Lin Yu, Jian Sun, Jiandong Ding

Theranostics · 2019 · 122 citations · 45 references

DOIFull text

Open access

Concepts

Abstract

: The Herceptin-loaded hydrogel has great potential for preventing the relapse of HER2+ breast tumors after breast-conserving surgery with enhanced therapeutic efficacy, improved patient compliance and significantly reduced side effects.

References

45

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 87.7K citations · Full text

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Cancer Immunotherapy

Jennifer Couzin-Frankel · Science · 2013 · 2K citations

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ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

Gabriele D’Uva, Alla Aharonov, Mattia Lauriola et al. · Nature Cell Biology · 2015 · 673 citations

, , +12

Oncoplastic approaches to partial mastectomy: an overview of volume-displacement techniques

Benjamin O. Anderson, Riccardo Masetti, Melvin J. Silverstein · The Lancet Oncology · 2005 · 353 citations

, , +13

Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I–III breast cancer (HannaH study): a phase 3, open-label, multicentre, randomised trial

Gustavo Ismael, Roberto Hegg, Susanne Muehlbauer et al. · The Lancet Oncology · 2012 · 346 citations

, , +17