Fbxw7 and Skp2 Regulate Stem Cell Switch between Quiescence and Mitotic Division in Lung Adenocarcinoma

Wenzhu Zhang, Zihan Ren, Lanling Jia, Xin Li, Xinshan Jia, Yuchen Han

BioMed Research International · 2019 · 17 citations · 30 references

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Abstract

5-FU enriches the CSCs in lung adenocarcinoma cells <i>via</i> increasing Fbxw7 and decreasing Skp2 expression, followed by downregulation of c-myc and upregulation of p27, which switches cells to quiescence.

References

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