Senescence, oxidative stress and mitochondria dysfunction

Abstract

Biological aging is known as senescence, and gradually leads to death through aging and mature organ deterioration. Senescence plays an important role in growth and development. Under the normal physiological conditions, the action of senescence is similar to apoptosis, and has a positive protective response to stimulation. However, in some pathological processes, the senescence effect may be positive or negative. To clarify the role of senescence in a certain disease, the exploration of its special regulation mechanism is the key to search for the new targets of the clinical treatment of disease. Oxidative stress is caused by excessive ROS involved in intracellular reactions and leads to the accumulation of oxidative damage to induce the changes in molecules, cells and tissues. The senescence is inseparable from oxidative stress, so the relationship between them has already become a hot issue of research. In this review, it will be focused on the research progress of senescence and the correlation of senescence with oxidative stress and mitochondrial dysfunction.