Concepedia

Publication | Open Access

Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial

DOIFull Paper Access

20

Citations

38

References

2019

Year

Astrid Johannesson Hjelholt, Kevin Y. Lee, Mai Christiansen Arlien-Søborg, Steen B. Pedersen, John J. Kopchick, Vishwajeet Puri, Niels Jessen, Jens Otto Lunde Jørgensen
Molecular Metabolism

Abstract

GH-induced lipolysis in human subjects in vivo is linked to downregulation of G0S2 and FSP27 and upregulation of PTEN in AT. Mechanistically, in vitro data suggest that GH acts via MEK to suppress PPARγ-dependent transcription of G0S2. ClinicalTrials.govNCT02782221 and NCT01209429.

References

YearCitations

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