Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.3K citations · Full text

Replicative Senescence, Developmental Biology, Aging +14

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5K citations · Full text

Developmental Biology, Oncogenic Agent, Cellular Senescence +6

Senescence of human fibroblasts induced by oncogenic Raf

Jiyue Zhu, Douglas Woods, Martin McMahon et al. · Genes & Development · 1998 · 800 citations · Full text

The metabolic footprint of aging in mice

Riekelt H. Houtkooper, Carmen Argmann, Sander M. Houten et al. · Scientific Reports · 2011 · 520 citations · Full text

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

Emma L. James, Ryan D. Michalek, Gayani Pitiyage et al. · Journal of Proteome Research · 2015 · 231 citations · Full text

Pathology, Cell Death, Redox Homeostasis +17