Science Advances · 2019 · 230 citations · 64 references
Life SciencesBiostatisticsGeneticsHuman GeneticsQuantitative GeneticsStatistical GeneticsComplex Trait GeneticsGenotype-by-environment InteractionGenotype-phenotype Association AnalysisPhenotypic VariationQuantitative Trait AnalysisQuantitative Trait LociGenome-wide Complex Trait AnalysisGenotype By Environment Interaction MappingGenotype By Environment Interaction ModelingGenotype-phenotype AssociationsObesity SusceptibilityQuantitative Trait Interaction AnalysisQuantitative Trait Loci By Environment InteractionQuantitative Trait Locus Interactions
for 9 traits, especially for those related to obesity. Direct GEI analysis with five environmental factors showed that the vQTLs were strongly enriched with GEI effects. Our results indicate pervasive GEI effects for obesity-related traits and demonstrate the detection of GEI without environmental data.
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