Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

Salvatore Oddo, Antonella Caccamo, Jason D. Shepherd et al. · Neuron · 2003 · 4.1K citations · Full text

Alzheimer's Disease, Dementia, Degenerative Disease +5

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

Ted Yednock, Catherine Cannon, Lawrence C. Fritz et al. · Nature · 1992 · 1.7K citations

Autoimmune Disease, Allergy, Autoantibody Production +10

A Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis

David H. Miller, Omar Khan, William Sheremata et al. · New England Journal of Medicine · 2003 · 1.2K citations · Full text

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

Elena Zenaro, Enrica Pietronigro, Vittorina Della Bianca et al. · Nature Medicine · 2015 · 831 citations

Inflammation, Lfa-1 Integrin, Neurodegenerative Diseases +11

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

Jody L. Baron, Joseph A. Madri, Nancy H. Ruddle et al. · The Journal of Experimental Medicine · 1993 · 828 citations · Full text

Immunology, Immune Regulation, Pathology +23