Concepedia

Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease

Gautam Goel, Jason A. Tye–Din, Shuo‐Wang Qiao, Amy K. Russell, Toufic Mayassi, Cezary Ciszewski, Vikas K. Sarna, Suyue Wang, Kaela E. Goldstein, John L. Dzuris,

Science Advances · 2019 · 128 citations · 32 references

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Abstract

Acute gastrointestinal symptoms induced by gluten, within 4 hours, are mediated by reactivation of antigen-specific memory T cells.

References

32

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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

Nathaniel R. West, Ahmed N. Hegazy, Benjamin M. J. Owens et al. · Nature Medicine · 2017 · 805 citations · Full text

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Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease

Jason A. Tye–Din, Jessica A. Stewart, James A. Dromey et al. · Science Translational Medicine · 2010 · 474 citations

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The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses

Willemijn Vader, Dariusz Stepniak, Y Kooy et al. · Proceedings of the National Academy of Sciences · 2003 · 382 citations · Full text

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Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma.

Ellen M Nilsen, Knut E. A. Lundin, Peter Krajči et al. · Gut · 1995 · 346 citations · Full text

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