Concepedia

Caspase‐3‐mediated GSDME activation contributes to cisplatin‐ and doxorubicin‐induced secondary necrosis in mouse macrophages

Feng‐Yi Mai, Pengyan He, Jiezhou Ye, Lihui Xu, Dong‐Yun Ouyang, Chenguang Li, Qiongzhen Zeng, Chenying Zeng, Chengcheng Zhang, Xian‐Hui He,

Cell Proliferation · 2019 · 71 citations · 17 references

DOIFull text

Open access

Abstract

Chemotherapeutic cisplatin and doxorubicin exerted their cytotoxicity on macrophages partly by inducing caspase-3/GSDME-mediated secondary necrosis.

References

17

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.2K citations

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature · 2017 · 3K citations

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Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Corey Rogers, Teresa Fernandes‐Alnemri, Lindsey Mayes et al. · Nature Communications · 2017 · 1.4K citations · Full text

Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice

Bao Lu, BARBARA J. RUTLEDGE, Long Gu et al. · The Journal of Experimental Medicine · 1998 · 1K citations · Full text