Technic of Controlled Drug Assay

Abstract

THE following report describes an assay and evaluation of chlorothiazide, hydrochlorothiazide and a placebo in a group of ambulatory patients with mild to moderately severe hypertension. The purpose of the study was threefold: to compare the action on blood pressure of these two diuretics as compared to a placebo in a "double-blind study," this being of importance in view of the well known impact of nonpharmacologic variables on blood pressure1 and the fact that adequately controlled studies of these two agents have been few; to determine if the greater weight-for-weight potency of hydrochlorothiazide as compared with chlorothiazide2 offered any advantage . . .