Hyperglycemia and Glycosuria Due to Thiazide Derivatives Administered in Diabetes Mellitus

Abstract

THE purpose of this communication is to call attention to the fact that the thiazides may cause aggravation of pre-existent diabetes mellitus, or the manifestation of the disease in predisposed persons. Awareness of this phenomenon is important for the practicing physician because of the wide use of these highly effective diuretic and hypotensive agents for oral administration.The following case illustrates the problem as we encountered it:Case ReportE.B., a 53-year-old woman, had been known to us since 1946 and had had repeated blood sugar determinations and urinalyses because of a family history of diabetes. She had never had . . .