Autophagy · 2019 · 171 citations · 19 references
Life SciencesCell BiologyMolecular BiologyAutophagyCell DivisionMitochondrial BiologyMitochondrial FissionMitochondrial FunctionMitochondrial FusionMitochondrial MetabolismMitochondrial PhysiologyMitophagyMitochondrial Degradation PathwaysMitochondrial Division MachineryMitochondrial Intermembrane Space ProteinsMitofusin 1Mitophagy ImpairmentPink1-parkin PathwayUbiquitin-mediated MitophagyUbiquitination Of Mitochondrial Proteins
DNM1L/DRP1: dynamin 1-like; KEAP1: kelch-like ECH-associated protein 1; KO: knockout; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MFN1/2: mitofusin 1/2; OPA1: OPA1, mitochondrial dynamin like GTPase; PDH: pyruvate dehydrogenase E1; PINK1: PTEN induced putative kinase 1; PRKN/parkin: parkin RBR E3 ubiquitin protein ligase.
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
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Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice
Masaaki Komatsu, Satoshi Waguri, Masato Koike et al. · Cell · 2007 · 2.1K citations · Full text
Ubiquitin is phosphorylated by PINK1 to activate parkin
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