Concepedia

Monitoring removal of hole-hole homodimer by analytical hydrophobic interaction chromatography in purifying a bispecific antibody

Tao Chen, Jin-Yu Han, Gaili Guo, Qing Wang, Ying Wang, Yifeng Li

Protein Expression and Purification · 2019 · 21 citations · 4 references

DOI

Concepts

References

4

‘Knobs-into-holes’ engineering of antibody C<sub>H</sub>3 domains for heavy chain heterodimerization

John Brady Ridgway, Leonard G. Presta, Paul Carter · Protein Engineering Design and Selection · 1996 · 802 citations

, , +15

A systematic approach for analysis and characterization of mispairing in bispecific antibodies with asymmetric architecture

Chunlei Wang, Bhargavi Vemulapalli, Mingyan Cao et al. · mAbs · 2018 · 51 citations · Full text

, , +14

Structural and Functional Characterization of a Hole–Hole Homodimer Variant in a “Knob-Into-Hole” Bispecific Antibody

Hui‐Min Zhang, Charlene Li, Ming Lei et al. · Analytical Chemistry · 2017 · 37 citations · Full text

, , +17

Characterization and quantification of succinimide using peptide mapping under low-pH conditions and hydrophobic interaction chromatography

Mingyan Cao, Sri Hari Raju Mulagapati, Bhargavi Vemulapalli et al. · Analytical Biochemistry · 2018 · 37 citations · Full text

, , +17