The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions

Carina Seitz, Juan Huang, Anna-Lena Geiselhöringer, Pamela Galbani-Bianchi, Svenja Michalek, Truong San Phan, Cindy Reinhold, Lea Dietrich, Christian Schmidt, Nadia Corazza,

Science Advances · 2019 · 30 citations · 27 references

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Abstract

T cells fail to control viral infections. This study describes a novel and critical role of LRH-1 in T cell maturation, functions, and immopathologies and proposes LRH-1 as an emerging pharmacological target in the treatment of T cell-mediated inflammatory diseases.

References

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