H2 Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction via Blocking TLR4-Mediated Cytokines Expression

Abstract

Key Results: LPS induced cardiac dysfunction; hydrogen therapy improved cardiac function after LPS challenge. Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of proinflammatory cytokines TNF, IL-1, and IL-18; suppressing the phosphorylation August 2019 | Volume 10 | Article 865 Frontiers in Pharmacology | www.frontiersin.org of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-B and the expression of TLR4 by LPS.