Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

Abstract

This is the first report detailing the effects of tissue-specific production of TNF-alpha by cardiac myocytes in vivo. These findings indicate that production of TNF-alpha by cardiac myocytes is sufficient to cause severe cardiac disease and support a causal role for this cytokine in the pathogenesis of human cardiac disease.