RETRACTED: Calpain silencing alleviates myocardial ischemia-reperfusion injury through the NLRP3/ASC/Caspase-1 axis in mice

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

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NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

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Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

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Veterinary Medicine, Cardiology, Pathobiology +17

NLRP3 Inflammasome Activation‐Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats

Zhen Qiu, Shaoqing Lei, Bo Zhao et al. · Oxidative Medicine and Cellular Longevity · 2017 · 358 citations · Full text

Veterinary Medicine, Cardiology, Pathobiology +16

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Gerardus P. J. van Hout, Lena Bosch, Guilielmus H.J.M. Ellenbroek et al. · European Heart Journal · 2016 · 322 citations · Full text

Medicine, Cardiology, Pharmacology +17