Concepedia

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against<i>Staphylococcus aureus</i>

Rong Deng, Dongwei Li, Hao Cai, Siddharth Sukumaran, Montserrat Carrasco‐Triguero, Ola M. Saad, Denise Nazzal, Christopher Lowe, Saroja Ramanujan, Amrita V. Kamath

mAbs · 2019 · 40 citations · 24 references

DOIFull text

Open access

Concepts

Abstract

: the volume of distribution for the peripheral compartment.

References

24

Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate

Kevin J. Hamblett, Peter D. Senter, Dana F. Chace et al. · Clinical Cancer Research · 2004 · 1.2K citations

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Ben‐Quan Shen, Keyang Xu, Luna Liu et al. · Nature Biotechnology · 2012 · 999 citations

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Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Sophie M. Lehar, Thomas H. Pillow, Min Xu et al. · Nature · 2015 · 833 citations

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Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data

Rong Deng, Suhasini Iyer, Frank‐Peter Theil et al. · mAbs · 2011 · 283 citations · Full text

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Effects of Drug–Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody–Maytansinoid Conjugates

Xiuxia Sun, Jose F. Ponte, Nicholas C. Yoder et al. · Bioconjugate Chemistry · 2017 · 253 citations

, , +17