Introduction of a Hydroxy Group onto 5- and 6-Position of Indole Nucleus by Friedel-Crafts Acylation and Subsequent Baeyer-Villiger Oxideation

Abstract

A hydroxy group was efficiently introduced onto 5and 6-position of methyl 1-methylindole-3-carboxylate l, and methyl indole-3-carboxylate 1 2 .Although there are many indole alkaloids containing oxygen functionls) at the benzene part of the indole nucleus, no efficient method for mtroduction of such functionls) has been reported except a few limited cases.lr2Oxidation of indole 4