Concepedia

Indene-Based Thiazolidinethione Chiral Auxiliary for Propionate and Acetate Aldol Additions

Antonio Osorio‐Lozada, Horacio F. Olivo

Organic Letters · 2008 · 44 citations · 17 references

DOI

Concepts

Abstract

An indene-based thiazolidinethione chiral auxiliary was prepared in two steps from trans-1-amino-2-indanol. Chlorotitanium enolates of this chiral auxiliary delivered excellent diastereoselectivities in propionate and acetate aldol additions. The chiral auxiliary was easily removed to deliver several valuable functionalities.

References

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