Concepedia

A Facile and Efficient Direct Aldol Addition of Simple Thioesters

Julianne M. Yost, Guoqiang Zhou, Don M. Coltart

Organic Letters · 2006 · 61 citations · 3 references

DOI

Concepts

Abstract

[reaction: see text] Simple thioesters undergo direct aldol addition to aldehydes in the presence of MgBr(2).OEt(2) and i-Pr(2)NEt using untreated, reagent-grade CH(2)Cl(2) under atmospheric conditions. The reactions proceed extremely rapidly and in excellent yield.

References

3

Catalytic Enantioselective Thioester Aldol Reactions That Are Compatible with Protic Functional Groups

Derek Magdziak, Gojko Lalić, Hong Myung Lee et al. · Journal of the American Chemical Society · 2005 · 182 citations

, , +13

An Exceptionally Mild Catalytic Thioester Aldol Reaction Inspired by Polyketide Biosynthesis

Gojko Lalić, Allen D. Aloise, Matthew D. Shair · Journal of the American Chemical Society · 2003 · 161 citations

, , +15

Heterocyclic betaines. Aza analogs of sesquifulvalene. 1. Structural studies of 1-alkyl-4-azolylidene-1,4-dihydropyridines and azolium azolate inner salts

Ermitas Alcalde, Immaculada Dinarès, Jordi Frigola et al. · The Journal of Organic Chemistry · 1991 · 39 citations

, , +9