Concepedia

Catalytic Enantioselective Thioester Aldol Reactions That Are Compatible with Protic Functional Groups

Derek Magdziak, Gojko Lalić, Hong Myung Lee, Kevin C. Fortner, Allen D. Aloise, Matthew D. Shair

Journal of the American Chemical Society · 2005 · 182 citations · 5 references

DOI

Concepts

Abstract

This communication reports highly enantioselective and diastereoselective methyl malonic acid half thioester (MeMAHT) aldol reactions that are compatible with protic functional groups and enolizable aldehydes, affording syn S-phenyl thiopropionates.

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