Synthesis and structure-activity relationships of novel 3′-Hty-substituted pneumocandins

The Emerging Fungal Threat

Steve Sternberg · Science · 1994 · 183 citations

Life Sciences, Biology, Microbiology +12

Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives

F. Aileen Bouffard, Robert A. Zambias, James F. Dropinski et al. · Journal of Medicinal Chemistry · 1994 · 112 citations

Pharmacy, Chemistry, Medicinal Chemistry +14

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin

Ken Bartizal, George K. Abruzzo, Charlotte Trainor et al. · Antimicrobial Agents and Chemotherapy · 1992 · 93 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis

Martha Kurtz, Cameron Douglas, J A Marrinan et al. · Antimicrobial Agents and Chemotherapy · 1994 · 71 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP)

James M. Balkovec, Regina M. Black, Milton L. Hammond et al. · Journal of Medicinal Chemistry · 1992 · 71 citations

Medicine, Medicinal Chemistry, Pharmacology +10