Intramolecular cyanoamidation of unsaturated cyanoformamides catalyzed by palladium: an efficient synthesis of multi-functionalized lactams

Nitrile-containing natural products

Fraser F. Fleming, Fraser F. Fleming · Natural Product Reports · 1999 · 670 citations

Pharmacy, Biochemistry, Chemistry +6

Palladium-Catalyzed Enantioselective C-3 Allylation of 3-Substituted-1<i>H</i>-Indoles Using Trialkylboranes

Barry M. Trost, Jean Quancard · Journal of the American Chemical Society · 2006 · 532 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones:  A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Flora Tang et al. · Journal of Medicinal Chemistry · 1998 · 488 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Enantioselective organocatalytic construction of pyrroloindolines by a cascade addition–cyclization strategy: Synthesis of (–)-flustramine B

Joel F. Austin, Sung-Gon Kim, Christopher J. Sinz et al. · Proceedings of the National Academy of Sciences · 2004 · 464 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +13

A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-acyltetrazoles from azides and acyl cyanides.

Zachary Demko, K. Barry Sharpless · PubMed · 2002 · 447 citations

Natural Sciences, Chemistry, Medicinal Chemistry +11