One Step Cascade Synthesis of 4,5-Disubstituted-1,2,3-(<i>NH</i>)-Triazoles

Abstract

A Lewis base-catalyzed three-component cascade reaction was developed for the synthesis of 4,5-disubstituted-1,2,3-(NH)-triazoles. More than 25 new (NH)-triazoles were prepared in good to excellent yields under mild conditions. The availability of the C-4 vinyl group allows easy conversion into other triazole derivatives.