Nucleosides and Nucleotides · 1996 · 13 citations · 17 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryMolecular VirologyVirologyAntiretroviral TherapyAntiviral AgentsAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyNucleic Acid SynthesisAntiviral Drug DesignAntiviral Natural ProductsAntiviral Structure-activity RelationshipsAntiviral TherapeuticsNon-nucleoside AntiviralsNucleoside AnalogsNucleoside Analogue AntiviralsNucleoside Analogue Therapy
Abstract Various 5-alkyl-6-aza-5,6-dihydrouridines and 6-(β-D-ribopyranosyl)-5-alkyl-6-aza-5,6-dihydrouracils have been synthesized. A new regioselective method is described for coupling triazinic bases to the sugar unit. Different epimers were isolated. Antiretroviral activity against Visna virus was evaluated.
17