Organic Letters · 2002 · 53 citations · 15 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistryOrganometallic ChemistryCarbonyl ChemistryChiral RecognitionChiral SeparationHeterocyclic ChemistryEnantiomer DiscriminationEnantioselective CatalysisEnantioselective SynthesisEnantioselectivityPlant Alkaloids
[reaction: see text] Highly enantioselective Reformatsky reaction of ketones was accomplished using cinchona alkaloids as chiral ligands. Chelation with the sp(2)-nitrogen adjacent to the reactive carbonyl center contributed the enantioface discrimination for the high enantioselectivities.
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