Synlett · 1997 · 10 citations · 0 references
Combinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryOligonucleotide SequenceNatural Sciences2',3'-Cyclopropanated Nucleoside DimersOligonucleotideMolecular BiologyConformational StudyOrganic ChemistryComplementary Rna SequencesRigid DimersChemistryChemical BiologyStructural BiologyLinear Chain Compound
Syntheses of three novel conformationally rigid dimers containing cyclopropyl -amide and -sulfonamide functionalities are described. Their incorporation into an oligonucleotide sequence resulted in considerable lowering of the Tm's in binding to their complementary RNA sequences.