Gould-Jacob Type of Reaction in the Synthesis of Thieno[3,2-e]pyrimido[1,2-c]pyrimidines: A Comparison of Classical Heating vs Solvent-Free Microwave Irradiation

Abstract

Gould-Jacob type of reaction for the synthesis of thieno[3,2e]pyrimido[l,Z-~Jpyrimidines (5) has been carried out conventionally by the condensation between 4-aminothieno[2,3qpyrimidines (3 and diethyl ethoxymethylenemdonate (2) via acyclic intermediates diethyl N-[5,6-disubstituted thieno[2,3-