Concepedia

Synthesis of Isoxazoles via Electrophilic Cyclization

Jesse P. Waldo, Richard C. Larock

Organic Letters · 2005 · 226 citations · 41 references

DOI

Concepts

Abstract

[reaction: see text] A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICl, I2, Br2, or PhSeBr.

References

41

A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara · Tetrahedron Letters · 1975 · 5.1K citations

, , +11

Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998

Akira Suzuki · Journal of Organometallic Chemistry · 1999 · 2.9K citations

, , +12

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2

John J. Talley, David Brown, Jeffery S. Carter et al. · Journal of Medicinal Chemistry · 2000 · 643 citations · Full text

, , +8

Synthesis of Isocoumarins and α-Pyrones via Electrophilic Cyclization

Tuanli Yao, Richard C. Larock · The Journal of Organic Chemistry · 2003 · 345 citations

, , +7

IPy<sub>2</sub>BF<sub>4</sub>‐Promoted Intramolecular Addition of Masked and Unmasked Anilines to Alkynes: Direct Assembly of 3‐Iodoindole Cores

José Barluenga, Mónica Trincado, Eduardo Rubio et al. · Angewandte Chemie International Edition · 2003 · 299 citations · Full text

, , +5